Marsh Institute Center for Technology, Environment and Development (CENTED), Clark University, 950 Main Street, Worcester, MA 01610, USA.
Environ Toxicol Pharmacol. 1997 Dec;4(3-4):195-208. doi: 10.1016/s1382-6689(97)10012-6.
This paper first reviews in plain language some basic concepts and methods for estimating inter-individual variability in susceptibility from human data. A scale is offered to allow different variability findings to be understood and compared. Then the accumulated results of different variability analyses, information on how much variability has been observed and how often, is summarized in the form of a series of box plots. Data are presented on pharmacodynamic variability for various non-cancer effects, variability in susceptibility to infectious organisms, and variability in susceptibility to carcinogenesis by genetically-acting agents.
本文首先用通俗易懂的语言回顾了从人体数据中估算个体易感性差异的一些基本概念和方法。提供了一个尺度，以便理解和比较不同的变异性发现。然后，以一系列箱线图的形式总结了不同变异性分析的累积结果、观察到的变异性程度以及观察到的频率信息。本文提供了各种非癌症效应的药效学变异性、对感染性生物体易感性的变异性以及遗传作用剂致癌易感性的变异性数据。
