Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Mol Cell Endocrinol. 2012 Apr 16;352(1-2):34-45. doi: 10.1016/j.mce.2011.06.033. Epub 2011 Jul 12.
Prostate cancer cells are exquisitely dependent on androgen receptor (AR) activity for proliferation and survival. As these functions are critical targets of therapeutic intervention for human disease, it is imperative to delineate the mechanisms by which AR engages the cell cycle engine. More than a decade of research has revealed that elegant intercommunication between AR and the cell cycle machinery governs receptor-dependent cellular proliferation, and that perturbations in this process occur frequently in human disease. Here, AR-cell cycle interplay and associated cancer relevance will be reviewed.
前列腺癌细胞的增殖和存活对雄激素受体 (AR) 的活性具有高度依赖性。由于这些功能是人类疾病治疗干预的关键靶点，因此必须阐明 AR 与细胞周期引擎相互作用的机制。十多年的研究表明，AR 与细胞周期机制之间的精细相互通讯控制着受体依赖性细胞增殖，并且该过程中的干扰在人类疾病中经常发生。在这里，将回顾 AR-细胞周期相互作用及其与癌症的相关性。
