Department of Pathology, Hematopathology Section and Lymph Node Registry, University of Kiel, Kiel, Germany.
Semin Hematol. 2011 Jul;48(3):148-54. doi: 10.1053/j.seminhematol.2011.03.006.
Mantle cell lymphoma (MCL) is a relatively rare lymphoma, accounting for less than 10% only of all lymphomas. Its morphology is quite homogeneous, but it varies strikingly in about 10% of the cases, making the diagnosis of MCL challenging for histopathologists. The definition of the disease was greatly influenced by the discovery of the translocation t(11;14)(q13,q32), which juxtaposes the cyclin D1 and the immunoglobulin heavy chain genes and is present in the vast majority of MCL cases. The introduction of monoclonal antibodies for the detection of cyclin D1 expression into the diagnostic procedure substantially improved the reproducibility and reliability of the pathological diagnosis. However, new challenges for histopathologists have arisen over the last years, among which are the detection of cyclin D1-negative MCL cases and clinically relevant prognostic subgroups.
套细胞淋巴瘤（MCL）是一种相对罕见的淋巴瘤，仅占所有淋巴瘤的不到 10%。其形态学非常均匀，但在大约 10%的病例中差异显著，这使得病理学家对 MCL 的诊断具有挑战性。该疾病的定义受到发现 t(11;14)(q13,q32)易位的极大影响，该易位使 cyclin D1 和免疫球蛋白重链基因并列，存在于绝大多数 MCL 病例中。将用于检测 cyclin D1 表达的单克隆抗体引入诊断程序极大地提高了病理诊断的可重复性和可靠性。然而，近年来病理学家面临着新的挑战，其中包括检测 cyclin D1 阴性的 MCL 病例和具有临床相关性的预后亚组。
