[The effect of the intracellular calcium concentration on GABA-activated ion currents in the neurons of the rat cerebellum].

Purkinje neurons from the rat cerebellum were investigated using a patch clamp technique. An increase in the concentration of intracellular calcium from 10(-8) to 10(-6) mol/l both considerably decreased the amplitude of the maximum GABA-activated chloride current and slightly reduced affinity of the GABA receptor.