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后颅窝减压技术治疗 Chiari 畸形伴脊髓空洞症的疗效分析。

An efficacy analysis of posterior fossa decompression techniques in the treatment of Chiari malformation with associated syringomyelia.

机构信息

Department of Neurosurgery, Research Institute of Surgery, DaPing Hospital, Third Military Medical University, 10 Changjiang Zhi Road, Chongqing 400042, China.

出版信息

J Clin Neurosci. 2011 Oct;18(10):1346-9. doi: 10.1016/j.jocn.2011.01.026. Epub 2011 Jul 22.

Abstract

A retrospective study of the efficacy of posterior fossa decompression (PFD) was carried out in 132 patients with Chiari malformation (CM) with associated syringomyelia (SM). Of these 132 patients, 69 received extended PFD (large craniotomy group), and the other 63 patients received only local PFD (small craniotomy group). At the short-term postoperative evaluation (1-4 weeks) the extended PFD appeared to be more effective than the local PFD (p<0.05). However, there was no significant difference in long-term analysis (6 months-11 years) (p>0.05). In the large craniotomy group, there was no difference between the short-term and long-term efficacy (p>0.05). However, in the small craniotomy group, long-term efficacy clearly improved (p<0.05). Furthermore, patients who had undergone local PFD exhibited more obvious radiological improvement of SM (p<0.05) and fewer postoperative complications compared to patients undergoing extended PFD (p<0.05). Therefore, local PFD is preferable for the surgical treatment of CM with associated SM.

摘要

回顾性研究了后颅窝减压(PFD)对伴有脊髓空洞症(SM)的 Chiari 畸形(CM)患者的疗效。132 例患者中,69 例行扩大 PFD(大骨瓣组),63 例行局部 PFD(小骨瓣组)。在短期术后评估(1-4 周)中,扩大 PFD 似乎比局部 PFD 更有效(p<0.05)。然而,长期分析(6 个月至 11 年)无显著差异(p>0.05)。在大骨瓣组中,短期和长期疗效无差异(p>0.05)。然而,在小骨瓣组中,长期疗效明显改善(p<0.05)。此外,与行扩大 PFD 相比,行局部 PFD 的患者 SM 的影像学改善更明显(p<0.05),术后并发症更少(p<0.05)。因此,局部 PFD 是治疗伴有 SM 的 CM 的首选手术方法。

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