Department of Dermatology, Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA.
Immunity. 2011 Aug 26;35(2):260-72. doi: 10.1016/j.immuni.2011.06.005. Epub 2011 Jul 21.
Skin-resident dendritic cells (DCs) are well positioned to encounter cutaneous pathogens and are required for the initiation of adaptive immune responses. There are at least three subsets of skin DC- Langerhans cells (LC), Langerin(+) dermal DCs (dDCs), and classic dDCs. Whether these subsets have distinct or redundant function in vivo is poorly understood. Using a Candida albicans skin infection model, we have shown that direct presentation of antigen by LC is necessary and sufficient for the generation of antigen-specific T helper-17 (Th17) cells but not for the generation of cytotoxic lymphocytes (CTLs). In contrast, Langerin(+) dDCs are required for the generation of antigen specific CTL and Th1 cells. Langerin(+) dDCs also inhibited the ability of LCs and classic DCs to promote Th17 cell responses. This work demonstrates that skin-resident DC subsets promote distinct and opposing antigen-specific responses.
皮肤固有树突状细胞（DC）能很好地接触皮肤病原体，并被要求启动适应性免疫反应。皮肤 DC 至少有三个亚群：朗格汉斯细胞（LC）、朗格汉斯细胞（Langerin+）真皮 DC（dDC）和经典 dDC。这些亚群在体内是否具有独特或冗余的功能尚不清楚。使用白色念珠菌皮肤感染模型，我们表明 LC 直接呈递抗原对于产生抗原特异性辅助性 T 细胞 17（Th17）细胞是必需且充分的，但对于产生细胞毒性 T 淋巴细胞（CTL）则不是必需的。相比之下，Langerin+ dDC 对于产生抗原特异性 CTL 和 Th1 细胞是必需的。Langerin+ dDC 还抑制 LC 和经典 DC 促进 Th17 细胞反应的能力。这项工作表明，皮肤固有树突状细胞亚群促进了独特和相反的抗原特异性反应。
