City of Hope Medical Center, Duarte, CA, USA.
Clin Colorectal Cancer. 2011 Dec;10(4):310-6. doi: 10.1016/j.clcc.2011.06.005. Epub 2011 Jul 22.
Colorectal cancer is common worldwide and chemoprevention has the potential of reducing the number of individuals who may suffer and perish from this disease.
A randomized placebo controlled pilot study in colorectal cancer patients was performed using calcium carbonate as the test agent in a multi-institutional oncology study group.
Two hundred twenty volunteers were randomized in the study. The primary goals of compliance, accrual, and toxicity monitoring are presented. Presence of multiple adenomas at study entry and subsequent development of metachronous adenomas were recorded and found to be associated with synchronous adenomas. The secondary endpoint of recurrent adenomas indicated lower rates of new adenoma in the volunteers randomized to the calcium group.
This pilot study indicates the feasibility of enrolling survivors of colorectal cancer as study volunteers in a colorectal neoplasm chemoprevention clinical trial and oral calcium continues to be a potentially effective drug in reducing colorectal adenomas.
结直肠癌在全球范围内较为常见，化学预防有潜力减少可能患病和死于该病的人数。
在一个多机构肿瘤研究组中，使用碳酸钙作为试验药物，对结直肠癌患者进行了一项随机安慰剂对照的初步研究。
220 名志愿者被随机分配到研究中。本文介绍了依从性、入组和毒性监测的主要目标。研究开始时存在多发性腺瘤和随后发生的同时性腺瘤被记录下来，并发现与同时性腺瘤有关。复发性腺瘤的次要终点表明，随机分配到钙组的志愿者中新腺瘤的发生率较低。
这项初步研究表明，招募结直肠癌幸存者作为研究志愿者参加结直肠新生物化学预防临床试验是可行的，口服钙仍然是一种降低结直肠腺瘤的有效药物。
