Department of Health Risk Analysis and Toxicology, Maastricht University, P.O. Box 616, 6200 MD Maastricht, The Netherlands.
Environ Toxicol Pharmacol. 2002 Jul;11(3-4):173-9. doi: 10.1016/s1382-6689(01)00115-6.
The occurrence of chemical contaminants with DNA-damaging capacity in the environment represents a threat to human health as well as to the health of the ecosystem. This mini-review describes studies that were aimed to monitor at field conditions, the presence of such environmental toxicants and their DNA-damaging effects in aquatic and terrestrial species, as well as in birds. It is obvious that these studies, in particular are abundantly performed in fish and aquatic invertebrates, have brought forward new information on the levels and genotoxic effects of these compounds which complements data coming from monitoring the abiotic fractions of the ecosystem, thereby demonstrating that the ecogenotoxicological approach is fruitful. However, in order to assess the genotoxic impact on the health of the ecosystem, a second generation type of field studies is required focusing on adverse effects on biodiversity and on survival potency. For this, the application of DNA microarray-based technologies provides new opportunities.
环境中具有 DNA 损伤能力的化学污染物的出现，不仅对人类健康，而且对生态系统的健康都构成了威胁。本综述描述了旨在现场条件下监测此类环境毒物及其在水生和陆生物种以及鸟类中的 DNA 损伤作用的研究。显然，这些研究，特别是在鱼类和水生无脊椎动物中进行的大量研究，提供了有关这些化合物水平和遗传毒性作用的新信息，补充了来自监测生态系统非生物部分的数据，从而表明生态遗传毒理学方法是富有成效的。然而，为了评估遗传毒性对生态系统健康的影响，需要开展第二代类型的现场研究，重点关注对生物多样性和生存能力的不利影响。为此，基于 DNA 微阵列的技术的应用提供了新的机会。
