Department of Physiology and Pharmacology, Interdisciplinary Neuroscience Program, Bowman Gray School of Medicine, Wake Forest University, Medical Center Boulevard, Winston-Salem, NC 27157-1083, USA.
Environ Toxicol Pharmacol. 2002 Sep;12(2):101-4. doi: 10.1016/s1382-6689(02)00028-5.
Methylmercury (MeHg) epidemics and studies in fish-eating populations have provided invaluable insights into the neurotoxic sequelae of MeHg exposure. MeHg is a ubiquitous environmental contaminant, and its accumulation in the food chain will continue to pose health risks given anthropogenic and natural contamination. This review briefly addresses recent epidemiological data associated with exposure to MeHg in fish-eating populations, identifies mechanisms of MeHg transport into the central nervous system (CNS), and discusses various theories on cellular processes afflicted by MeHg, which most certainly include astrocytic failure to maintain the composition of the extracellular fluid.
甲基汞（MeHg）流行病学和食鱼人群研究为了解甲基汞暴露的神经毒性后果提供了宝贵的见解。甲基汞是一种普遍存在的环境污染物，由于人为和自然污染，其在食物链中的积累将继续构成健康风险。本综述简要介绍了与食鱼人群接触甲基汞相关的最新流行病学数据，确定了甲基汞进入中枢神经系统（CNS）的转运机制，并讨论了受甲基汞影响的各种细胞过程理论，其中肯定包括星形胶质细胞无法维持细胞外液组成的情况。
