Department of Biomedical Science, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan; CREST, Japan Science and Technology Corporation, Kawaguchi-shi, Saitama 332-0012, Japan.
Environ Toxicol Pharmacol. 2003 Sep;14(3):99-108. doi: 10.1016/S1382-6689(03)00044-9.
The objective of this investigation is to evaluate whether perinatal maternal exposure to bisphenol A (BPA) at 4, 40, and 400 mg/kg per day affects the behavior of offspring in F344 rats. Perinatal BPA exposure inhibited the body weight increases of male and female offspring in a dose-dependent manner, which continued after weaning. Spontaneous activity analyses revealed that BPA elongated immobile time during the dark phase in female offspring. At 4 weeks of age, male offspring exposed to BPA at 40 and 400 mg/kg per day performed avoidance responses significantly higher in the shuttlebox avoidance test. At 8 weeks of age, however, male offspring only at 4 mg/kg per day showed significantly lower responses. In the open-field behavior test at 8 weeks of age, male offspring exposed to BPA only at 4 mg/kg per day showed a higher percent of grooming than the control male offspring. In conclusion, perinatal exposure to BPA caused the behavioral alterations in the offspring.
本研究旨在评估围产期母鼠每天暴露于 4、40 和 400mg/kg 的双酚 A（BPA）是否会影响 F344 大鼠后代的行为。围产期 BPA 暴露以剂量依赖的方式抑制雄性和雌性后代的体重增加，这种抑制作用持续到断奶后。自发活动分析显示，BPA 延长了雌性后代在暗期的不动时间。在 4 周龄时，暴露于 40 和 400mg/kg/day 的 BPA 的雄性后代在穿梭箱回避测试中表现出显著更高的回避反应。然而，在 8 周龄时，只有每天暴露于 4mg/kg 的雄性后代表现出显著较低的反应。在 8 周龄的旷场行为测试中，仅每天暴露于 4mg/kg 的 BPA 的雄性后代的修饰行为百分比高于对照组雄性后代。总之，围产期暴露于 BPA 导致了后代的行为改变。
