Department of Endocrinology and Thyroid Research Centre, Institute of Nuclear Medicine & Allied Sciences, Delhi, India.
Clin Biochem. 2011 Oct;44(14-15):1214-7. doi: 10.1016/j.clinbiochem.2011.07.003. Epub 2011 Jul 19.
In view of inconsistent reports on the prevalence of dyslipidemia in subclinical hypothyroidism (SCH), we studied lipid abnormalities in Indian subjects with SCH.
A cross sectional study of 5343 subjects divided in two groups, Group-1 (age≤18 years) and Group-2 (age>18 years) was undertaken. They were further subdivided on the basis of their thyroid functional status: Normal (Control); SCH with TSH≤10.0mIU/L (SCH-1); and SCH with TSH>10mIU/L (SCH-2).
Prevalence of SCH was 14.7%. The only lipid abnormality in children and adolescents was low HDL in subjects with TSH>10mIU/L compared with controls. Serum total cholesterol (TC), and LDL cholesterol (LDL) were significantly higher in adults with TSH>10mIU/L compared to controls. There were no significant changes in lipid parameters in subjects with SCH having TSH≤10.0mIU/L, compared to controls. Serum TSH was positively and FT3 and FT4 were negatively correlated with TC and LDL.
Atherogenic lipid abnormalities were observed in adult subjects with SCH-2 (TSH>10.0mIU/L), and not in subjects with SCH-1 who had TSH≤10.0mIU/L in Indian population.
鉴于亚临床甲状腺功能减退症（SCH）患者血脂异常的患病率存在不一致的报告，我们研究了印度 SCH 患者的脂质异常。
对 5343 名受试者进行了一项横断面研究，将他们分为两组，第 1 组（年龄≤18 岁）和第 2 组（年龄>18 岁）。根据他们的甲状腺功能状态进一步细分：正常（对照组）；促甲状腺激素（TSH）≤10.0mIU/L 的 SCH（SCH-1）；和 TSH>10mIU/L 的 SCH（SCH-2）。
SCH 的患病率为 14.7%。儿童和青少年唯一的脂质异常是 TSH>10mIU/L 的受试者的 HDL 较低，与对照组相比。与对照组相比，TSH>10mIU/L 的成年人的血清总胆固醇（TC）和 LDL 胆固醇（LDL）明显更高。与对照组相比，TSH≤10.0mIU/L 的 SCH 患者的血脂参数没有明显变化。血清 TSH 与 TC 和 LDL 呈正相关，FT3 和 FT4 与 TC 和 LDL 呈负相关。
在印度人群中，仅在 SCH-2（TSH>10.0mIU/L）的成年患者中观察到致动脉粥样硬化的脂质异常，而在 TSH≤10.0mIU/L 的 SCH-1 患者中没有观察到这种异常。
