Akici N, Onal Z E, Gürbüz T, Sağ C, Kilinç S
Istanbul Haydarpasa Numune Training and Research Hospital - Department of Pediatrics, Istanbul, Turkey.
Bagcilar Training and Research Hospital, Istanbul, Turkey.
Acta Endocrinol (Buchar). 2020 Jul-Sep;16(3):334-338. doi: 10.4183/aeb.2020.334.
The frequency of subclinical hypothyroidism (SH) in patients with obesity is increased compared with the normal population. However, data on the risk of cardiovascular disease (CVD) in patients with SH are still scarce. Lipid parameters are strong predictors of early CVD. We aimed to investigate the role of lipid indices in predicting CVD risk compared to conventional lipid components.
A total of 220 euthyroid obese children (EU) and 90 obese children with SH were included in the study. All data were collected from hospital files. Lipid indices were evaluated. Atherogenic index of plasma (AIP), cardiac risk ratio (CRR) and atherogenic coefficient (AC) were calculated. AIP>0.24, CRR>5 ve AC>3 were considered as cardiovascular risk criteria.
The presence of SH increased the risk of higher AIP and the risk of CRR, compared to euthyroid obese children.
Subclinical hypothyroidism in obese children may cause dislipidemia carrying a high cardiovascular disease risk.
与正常人群相比，肥胖患者亚临床甲状腺功能减退（SH）的发生率有所增加。然而，关于SH患者心血管疾病（CVD）风险的数据仍然很少。血脂参数是早期CVD的有力预测指标。我们旨在研究与传统脂质成分相比，脂质指标在预测CVD风险中的作用。
本研究共纳入220例甲状腺功能正常的肥胖儿童（EU）和90例患有SH的肥胖儿童。所有数据均从医院病历中收集。评估脂质指标。计算血浆致动脉粥样硬化指数（AIP）、心脏风险比（CRR）和致动脉粥样硬化系数（AC）。AIP>0.24、CRR>5和AC>3被视为心血管风险标准。
与甲状腺功能正常的肥胖儿童相比，SH的存在增加了AIP升高的风险和CRR风险。
肥胖儿童的亚临床甲状腺功能减退可能导致具有高心血管疾病风险的血脂异常。
