Programa de Fisiología y Biofísica, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile.
Mol Cell Neurosci. 2011 Dec;48(4):269-77. doi: 10.1016/j.mcn.2011.07.001. Epub 2011 Jul 19.
The highly polarized morphology and complex geometry of neurons is determined to a great extent by the structural and functional organization of the secretory pathway. It is intuitive to propose that the spatial arrangement of secretory organelles and their dynamic behavior impinge on protein trafficking and neuronal function, but these phenomena and their consequences are not well delineated. Here we analyze the architecture and motility of the archetypal endoplasmic reticulum (ER), and their relationship to the microtubule cytoskeleton and post-translational modifications of tubulin. We also review the dynamics of the ER in axons, dendrites and spines, and discuss the role of ER dynamics on protein mobility and trafficking in neurons.
神经元的高度极化形态和复杂几何形状在很大程度上取决于分泌途径的结构和功能组织。人们直观地认为，分泌细胞器的空间排列及其动态行为会影响蛋白质运输和神经元功能，但这些现象及其后果尚不清楚。在这里，我们分析了典型内质网（ER）的结构和运动及其与微管细胞骨架和微管蛋白翻译后修饰的关系。我们还回顾了轴突、树突和棘突中 ER 的动力学，并讨论了 ER 动力学在神经元中蛋白质流动性和运输中的作用。
