Biology Department, University of Massachusetts Amherst, Amherst, MA 01003, USA.
Curr Biol. 2011 Jul 26;21(14):R557-9. doi: 10.1016/j.cub.2011.06.020.
Separating mitotic error correction, chromosome biorientation and the spindle assembly checkpoint (SAC) is complicated by their interconnected relationships. New research finds that Aurora B kinase, which drives error correction and promotes biorientation, also directly regulates the SAC.
有丝分裂错误校正、染色体双定向和纺锤体组装检查点(SAC)之间的相互关系使得它们难以分离。新的研究发现,驱动错误校正和促进双定向的 Aurora B 激酶也直接调节 SAC。