Department of Veterinary Pharmacology and Toxicology, CCS Haryana Agricultural University, Hisar, India.
Environ Toxicol Pharmacol. 2005 May;19(3):471-6. doi: 10.1016/j.etap.2004.12.009. Epub 2005 Feb 12.
The organophosphate pesticides exhibit their action by inhibiting acetylcholinesterase (AChE) enzyme in central and peripheral nervous system. They are known to affect the young animals to a greater extent, as their developing brain is more susceptible to their toxic effects. Besides inactivating acetylcholine at synaptic terminals AChE also plays an important role in neuronal growth and differentiation. A reduction in AChE activity in plasma has no known physiological function in causing brain or tissue damage, but if a good correlation between brain and plasma AChE inhibition exists, then circulating plasma AChE can be used as a reliable marker for detection of cholinesterase inhibitors. Therefore, the present investigation was designed to differentiate age and gender related neurotoxicity of an organophosphate pesticide-triazophos and to explore whether plasma AChE can serve as a biomarker of its neurotoxicity in young, i.e. post natal days 20 (PND 20) and adult rats i.e. post natal days 90 (PND 90) after single intraperitoneal administration in different doses.
有机磷农药通过抑制中枢神经系统和外周神经系统中的乙酰胆碱酯酶（AChE）发挥作用。已知它们对年幼动物的影响更大，因为它们发育中的大脑更容易受到其毒性影响。除了在突触末端失活乙酰胆碱外，AChE 在神经元生长和分化中也起着重要作用。血浆中 AChE 活性的降低在引起脑或组织损伤方面没有已知的生理功能，但是如果脑和血浆 AChE 抑制之间存在良好的相关性，那么循环血浆 AChE 可以用作检测胆碱酯酶抑制剂的可靠标志物。因此，本研究旨在区分有机磷农药三唑磷的年龄和性别相关神经毒性，并探讨血浆 AChE 是否可以作为其在幼鼠（出生后 20 天，PND 20）和成年大鼠（出生后 90 天，PND 90）神经毒性的生物标志物在单次腹腔内给予不同剂量后。
