Department of Physiology, Dr. ALM PG Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai 600-113, India.
Environ Toxicol Pharmacol. 2005 Jul;20(1):142-8. doi: 10.1016/j.etap.2004.12.059.
The levels of free radical scavenging enzymes in six discrete brain regions (cerebral cortex, cerebellum, midbrain, pons medulla, hippocampus and hypothalamus), after exposure to three different durations of noise stress (broadband white noise, 100dB, 4h/day, in acute: 1 day, sub acute: 15 days and chronic stress: 30 days) was studied in Wister strain male albino rats. Acute noise stress significantly increases the levels of superoxide dismutase (SOD: EC 1.15.1.1), catalase (EC 1.11.1.6), glutathione peroxidase (GPx: EC 1.11.1.9), oxidized glutathione (GSSG) and lipid peroxidation (LPO) and decreases the levels of reduced glutathione (GSH), GSH/GSSG ratio and protein thiols. The free radical scavenging enzymes levels, in sub acute and chronic noise stress also showed marked deviation in certain regions from the controls within the study duration. The results indicate that adaptation to noise stress does not occur immediately in all the brain regions. The noise induced alterations in free radicals may be assumed to serve as a linkage between the environmental noise and the manifestation of multifactorial diseases attributed to noise exposure. Moreover the quantification of the health effects of noise by the alterations in free radicals seems inappropriate in chronic noise stress.
研究了 Wister 品系雄性白化大鼠在暴露于三种不同持续时间的噪声应激（宽带白噪声，100dB，每天 4 小时）后，六个离散脑区（大脑皮层、小脑、中脑、脑桥延髓、海马体和下丘脑）中自由基清除酶的水平。急性噪声应激显著增加超氧化物歧化酶（SOD：EC 1.15.1.1）、过氧化氢酶（CAT：EC 1.11.1.6）、谷胱甘肽过氧化物酶（GPx：EC 1.11.1.9）、氧化型谷胱甘肽（GSSG）和脂质过氧化（LPO）的水平，并降低还原型谷胱甘肽（GSH）、GSH/GSSG 比值和蛋白质巯基的水平。亚急性和慢性噪声应激中的自由基清除酶水平也在研究期间的某些区域显示出与对照组的明显偏差。结果表明，所有脑区对噪声应激的适应并非立即发生。自由基的噪声诱导变化可能被认为是环境噪声与归因于噪声暴露的多因素疾病表现之间的联系。此外，通过自由基的变化来量化噪声对健康的影响在慢性噪声应激中似乎是不合适的。
