Department of Food and Nutrition, Hung Kuang University, Taichung 433, Taiwan, ROC.
Environ Toxicol Pharmacol. 2006 Jan;21(1):1-7. doi: 10.1016/j.etap.2005.03.010. Epub 2005 Jun 13.
Polyamines are involved in cellular growth, differentiation and regulation of oxidative stress. The present investigation was to determine the effect of aluminum (Al) toxicity on the nitric oxide products (NO(x)) and metabolism of polyamines in mouse testes and epididymis. Aluminum chloride, AlCl(3,) was administered intraperitoneally to CD-1 adult male mice at dosages of 0, 7 or 35mg Al/kg body weight/day for 14 days (C, LAL and HAL groups). Results obtained show that the weights of epididymis in HAL animals are significantly decreased due to Al administration. Al treatment significantly induced higher Al concentrations in serum, testis and epididymis tissue. In addition, the serum and testicular and epididymal NO(x) production in HAL and testicular NO(x) in LAH groups were increased remarkably compared to the control animals. On the contrary, the contents of putrescine and spermine in testis were significantly lower than the values of controls and LAL groups. The epididymal spermine levels of HAL animal also decreased significantly. It is suggested that the polyamine biosynthesis in the mouse testis and epididymis can be affected by Al, which is associated with the NO(x) production in the male reproductive toxicity.
多胺参与细胞生长、分化和氧化应激的调节。本研究旨在确定铝（Al）毒性对小鼠睾丸和附睾中一氧化氮产物（NOx）和多胺代谢的影响。用氯化铝（AlCl3）以 0、7 或 35mg Al/kg 体重/天的剂量腹腔内给予 CD-1 成年雄性小鼠 14 天（C、LAL 和 HAL 组）。结果表明，由于铝的给予，HAL 动物的附睾重量显著降低。铝处理显著诱导血清、睾丸和附睾组织中更高的铝浓度。此外，与对照组动物相比，HAL 和 LAH 组的血清和睾丸及附睾 NOx 产生以及睾丸 NOx 在 HAL 组中显著增加。相反，睾丸中腐胺和精胺的含量明显低于对照组和 LAL 组的值。HAL 动物附睾中的精胺水平也显著降低。这表明，Al 可影响小鼠睾丸和附睾中的多胺生物合成，这与男性生殖毒性中的 NOx 产生有关。
