交通污染物暴露男性工人的血浆 IL-2、NK、IFN-γ 和 C3。

Plasma IL-2, NK, IFN-γ, and C3 in male workers exposed to traffic pollutants.

机构信息

University of Rome "La Sapienza", Department of Occupational Medicine, Viale Regina Elena 336, 00161 Rome, Italy.

出版信息

Environ Toxicol Pharmacol. 2006 Sep;22(2):131-5. doi: 10.1016/j.etap.2006.01.003. Epub 2006 Feb 28.

DOI:10.1016/j.etap.2006.01.003

Abstract

The aim of the study is to evaluate if the occupational exposure to urban stressors could cause alterations in interleukin-2 (IL-2), NK, interferon-γ (IFN-γ) and C3 plasma levels in male traffic police officers compared to controls. After excluding the principal confounding factors, 108 traffic police officers were matched with 108 controls by age, working life, habitual consumption of alcohol and spirits. IL-2 mean levels were significantly higher in traffic police officers compared to controls (p=0.04). The distribution of IL-2 values in traffic police officers and in controls was significant (p=0.01). The distribution of NK value percentage in traffic police officers and in controls was significant (p=0.000). IFN-γ and C3 mean levels were not significant in traffic police officers compared to controls. Our results suggest that the occupational chronic exposure to low doses of urban stressors could affect NK and IL-2 plasma concentrations in traffic police officers of male sex.

摘要

本研究旨在评估男性交通警察在职业环境中接触城市应激源是否会导致白细胞介素-2 (IL-2)、自然杀伤 (NK)、干扰素-γ (IFN-γ) 和 C3 血浆水平发生变化，并与对照组进行比较。在排除主要混杂因素后，108 名交通警察与 108 名对照组按照年龄、工作年限、习惯性饮酒和饮酒习惯进行匹配。与对照组相比，交通警察的 IL-2 平均水平显著升高（p=0.04）。交通警察和对照组的 IL-2 值分布差异有统计学意义（p=0.01）。交通警察和对照组的 NK 值百分比分布差异有统计学意义（p=0.000）。与对照组相比，交通警察的 IFN-γ 和 C3 平均水平无显著差异。我们的结果表明，职业性慢性接触低剂量城市应激源可能会影响男性交通警察的 NK 和 IL-2 血浆浓度。