Ciarrocca Manuela, Tomei Francesco, Bernardini Andrea, Capozzella Assuntina, Fiore Pina, Amicarelli Vittoria, Sancini Angela, Perugi Federica, Firullo Erica, Rosati Maria Valeria, Pimpinella Benedetta, Monti Carlo, Tomei Gianfranco
University of Rome La Sapienza, Department of Occupational Medicine, Viale Regina Elena 336, 00161 Rome, Italy.
Sci Total Environ. 2006 Oct 15;370(1):17-22. doi: 10.1016/j.scitotenv.2006.05.015. Epub 2006 Jul 7.
Urban outside workers, such as traffic police, are daily exposed to air pollutants and psychosocial stressors: for these workers, the working environment corresponds to the living environment of the general population. Studies in the literature have shown that immune parameters could be affected by chronic exposure to various chemical pollutants. The aim of this study is to evaluate whether occupational exposure to urban pollutants can cause alterations in NK, IL-2, IFN-gamma and C3 plasma levels in female traffic police compared to a control group. After excluding subjects with the principal confounding factors, 86 female traffic police and 87 controls were matched by age, years of police work and habitual alcohol consumption. The distribution of NK values in female traffic police and controls was significantly different (p=0.000); NK values above the upper limit of the normal laboratory range were observed in 23 female traffic police and in 2 controls (p=0.000). IL-2 mean levels were higher in traffic police compared to controls, but the difference was not significant. The mean and the distribution of IFN-gamma values in female traffic police and controls were not different. C3 mean levels were higher in female traffic police versus controls, but the difference was not significant. Considering that the subjects with the principal confounding factors were excluded from the study and that female traffic police and controls were matched by the above-mentioned variables, our results suggest that chronic occupational exposure to low doses of chemical stressors, which may interact with and add to psychosocial ones, can affect both innate and adaptative immunity.
城市户外工作者，如交警，每天都暴露于空气污染物和心理社会压力源中：对于这些工作者而言，工作环境等同于普通人群的生活环境。文献研究表明，长期接触各种化学污染物可能会影响免疫参数。本研究的目的是评估与对照组相比，职业性接触城市污染物是否会导致女性交警的自然杀伤细胞（NK）、白细胞介素-2（IL-2）、干扰素-γ（IFN-γ）和补体C3血浆水平发生改变。在排除具有主要混杂因素的受试者后，86名女性交警和87名对照组人员按照年龄、警龄和习惯性饮酒情况进行了匹配。女性交警和对照组的NK值分布存在显著差异（p = 0.000）；在23名女性交警和2名对照组人员中观察到NK值高于正常实验室范围的上限（p = 0.000）。与对照组相比，交警的IL-2平均水平较高，但差异不显著。女性交警和对照组的IFN-γ值的平均值和分布没有差异。女性交警的C3平均水平高于对照组，但差异不显著。鉴于本研究排除了具有主要混杂因素的受试者，且女性交警和对照组在上述变量方面进行了匹配，我们的结果表明，长期职业性接触低剂量的化学应激源，可能与心理社会应激源相互作用并叠加，会影响先天免疫和适应性免疫。
