从麻柳树中分离得到的糖蛋白可调节小鼠结肠组织中与炎症相关的因子。
Glycoprotein isolated from Ulmus davidiana Nakai modulates inflammatory related factors in mouse colonic tissues.
机构信息
Molecular Biochemistry Laboratory, Biotechnology Research Institute & Center for the Control of Animal Hazards using Biotechnology (BK 21), Chonnam National University, 300 Yongbong-Dong, Kwangju 500-757, South Korea.
出版信息
Environ Toxicol Pharmacol. 2007 Mar;23(2):234-41. doi: 10.1016/j.etap.2006.10.005. Epub 2006 Nov 30.
This study was carried out to investigate the anti-inflammatory effects of a 116kDa glycoprotein isolated from Ulmus davidiana Nakai (UDN glycoprotein) in dextran sodium sulfate (DSS)-treated mice. In DSS-treated mouse, the results showed that pretreatment with UDN glycoprotein [40mg/kg body weight (BW)] normalized the augment of disease activity index (DAI) level and shortening of the large intestine. In addition, UDN glycoprotein inhibited myeloperoxidase (MPO) activation, thiobarbituric acid reactive substances (TBARS) formation, nitric oxide (NO) production and lactate dehydrogenase (LDH) release, whereas increased the activity of anti-oxidant enzymes [superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx)], accompanying the inhibition of pro-inflammatory-related signal mediators [colonic nuclear factor-kappa B (NF-κB), inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2)] in DSS-stimulated mice colitis. These results speculate that UDN glycoprotein may be useful for prevention of inflammatory disease and colorectal carcinogenesis.
本研究旨在探讨从川榆（Ulmus davidiana Nakai）中分离得到的 116kDa 糖蛋白（UDN 糖蛋白）对葡聚糖硫酸钠（DSS）诱导的小鼠的抗炎作用。在 DSS 处理的小鼠中，结果表明，UDN 糖蛋白预处理[40mg/kg 体重（BW）]可使疾病活动指数（DAI）水平升高和大肠缩短正常化。此外，UDN 糖蛋白抑制髓过氧化物酶（MPO）活化、硫代巴比妥酸反应物质（TBARS）形成、一氧化氮（NO）产生和乳酸脱氢酶（LDH）释放，同时增加抗氧化酶[超氧化物歧化酶（SOD）、过氧化氢酶（CAT）和谷胱甘肽过氧化物酶（GPx）]的活性，伴随抑制 DSS 刺激的小鼠结肠炎中促炎相关信号介质[结肠核因子-κB（NF-κB）、诱导型一氧化氮合酶（iNOS）和环氧化酶-2（COX-2）]。这些结果表明，UDN 糖蛋白可能对预防炎症性疾病和结直肠癌变有用。
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