Laboratory of Radiation Biology, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, 52-1 Yada, Shizuoka-shi 422-8526, Japan.
Environ Toxicol Pharmacol. 2007 Mar;23(2):256-63. doi: 10.1016/j.etap.2006.09.002. Epub 2006 Sep 15.
Polycyclic aromatic hydrocarbons (PAHs) are widely distributed in the environment as pollutants in air, water and soil, and some are carcinogenic, being associated with various types of cancer. A majority of the research concerning the biological effects of PAHs has focused on the metabolic activation and DNA adducts leading to mutation and transformation. Although the role of the PAHs as photosensitizers has received much less attention, investigators have shown that PAHs excited by sunlight induced significant cytotoxicity and several kinds of DNA damage. Some PAHs were recently proved to be photomutagenic. In this review, we discuss the influence of PAHs in combination with sunlight focusing on the phototoxicity and cellular DNA damage produced.
多环芳烃（PAHs）作为空气、水和土壤中的污染物广泛存在于环境中，其中一些具有致癌性，与各种类型的癌症有关。大多数关于 PAHs 生物效应的研究都集中在代谢激活和 DNA 加合物导致突变和转化上。尽管 PAHs 作为光敏剂的作用受到的关注较少，但研究人员已经表明，阳光激发的 PAHs 会导致明显的细胞毒性和多种类型的 DNA 损伤。最近有研究证明，一些 PAHs 具有光致突变性。在这篇综述中，我们讨论了 PAHs 与阳光结合产生的光毒性和细胞 DNA 损伤的影响。
