女贞子对糖尿病高脂血症大鼠心肌缺血再灌注损伤所致胆固醇水平及心律失常发生的影响。

Effects of Ligustrum delavayanum Hariot. on cholesterol levels and arrhythmogenesis induced by myocardial ischaemia-reperfusion injury in diabetic-hypercholesterolaemic rats.

机构信息

Department of Pharmacology and Toxicology Faculty of Pharmacy, Comenius University, Bratislava, Slovak Republic.

出版信息

Environ Toxicol Pharmacol. 2008 Sep;26(2):255-8. doi: 10.1016/j.etap.2008.03.012. Epub 2008 Mar 29.

DOI:10.1016/j.etap.2008.03.012

Abstract

The present study was conducted to determine the effects of Ligustrum delavayanum Hariot. (Oleaceae) on cholesterol levels and the outcome of myocardial reperfusion injury in diabetic-hypercholesterolaemic rats. Per orally daily administration of a Ligustrum infusion (1000mg/kg, calculated on the dry plant material) to the rats with induced diabetes and hypercholesterolaemia significantly reduced the liver total cholesterol content. Similarly, increased severity of reperfusion arrhythmias in the double-diseased rats was diminished upon Ligustrum-treatment. These results suggest a potential use of Ligustrum in the prevention/therapy of risk factors and coronary heart disease itself.

摘要

本研究旨在探讨女贞子（木樨科）对糖尿病高脂血症大鼠胆固醇水平和心肌再灌注损伤结果的影响。每日经口给予糖尿病和高脂血症大鼠女贞子煎剂（1000mg/kg，按干植物材料计算）可显著降低肝脏总胆固醇含量。同样，女贞子治疗可减轻双病变大鼠再灌注心律失常的严重程度。这些结果表明女贞子可能具有预防/治疗危险因素和冠心病本身的作用。