Dow AgroSciences LLC, 9330 Zionsville Rd., Indianapolis, IN 46268, USA.
Food Chem Toxicol. 2011 Oct;49(10):2667-9. doi: 10.1016/j.fct.2011.07.018. Epub 2011 Jul 19.
The safety assessment for transgenic food crops currently includes an evaluation of the endogenous allergy potential (via serum IgE screening) when the non-transgenic counterpart is a commonly allergenic food. The value of this analysis in the safety assessment of transgenic crops, especially with reference to recent requests to quantify individual allergen concentrations in raw commodities, is examined. We conclude that the likelihood of upregulating an endogenous allergen due to transgenesis is no greater than from traditional breeding which has a history of safety and is largely unregulated. The potential consequences of upregulating an endogenous allergen are also unclear.
转基因食品作物的安全性评估目前包括对非转基因对应物为常见过敏原的食物的内源性过敏潜力（通过血清 IgE 筛选）进行评估。本文研究了该分析在转基因作物安全性评估中的价值，特别是在最近要求量化原料中单个过敏原浓度的情况下。我们的结论是，由于转基因而导致内源性过敏原上调的可能性并不大于传统育种，后者具有安全的历史且在很大程度上不受监管。上调内源性过敏原的潜在后果也不清楚。
