Department of Neurology, Union Hospital Affiliated to Fujian Medical University, Fuzhou, China.
Biomed Environ Sci. 2011 Jun;24(3):228-33. doi: 10.3967/0895-3988.2011.03.004.
To investigate the association between quality of life (QOL) and sociodemographic factors, clinical seizure factors, depression and anxiety in patients suffering from epilepsy.
We examined 141 consecutive patients with epilepsy (mean age 25.8±9.6, 61.7% male). All patients completed the Self-Rating Depression Scale, Self-Rating Anxiety Scale, WHOQOL-BREF and QOLIE-31(Chinese version). Multiple linear regression analyses were applied to investigate factors impact on QOL.
The results revealed that scores on two domains of the WHOQOL-BREF (i.e., physical and psychological domains, P<0.05) were significantly lower in the epilepsy group compared with the control group. Multiple regression analyses showed that anxiety, depression and course explained approximately 40% of the variance in patients' QOL. Anxiety was consistently the strongest predictor of lower scores on almost all QOL domains. In addition, the severity of depressive symptoms was significantly associated with lower scores across many QOL domains.
Our findings suggest that QOLIE scores might be substantially affected by the presence and severity of anxiety symptoms and, to a lesser degree, of depressive symptoms and prolonged course of illness. In contrast, clinical seizure variables had a weaker association with QOL. Healthcare professionals should be aware of the significance of patients' emotional state and of the role it plays in their QOL.
探讨生活质量（QOL）与社会人口学因素、临床发作因素、抑郁和焦虑在癫痫患者中的关系。
我们检查了 141 例连续癫痫患者（平均年龄 25.8±9.6，61.7%为男性）。所有患者均完成了自评抑郁量表、自评焦虑量表、WHOQOL-BREF 和 QOLIE-31（中文版）。采用多元线性回归分析来探讨影响 QOL 的因素。
结果显示，与对照组相比，WHOQOL-BREF 的两个领域（即身体和心理领域，P<0.05）的评分在癫痫组中显著较低。多元回归分析表明，焦虑、抑郁和病程解释了患者 QOL 约 40%的方差。焦虑一直是几乎所有 QOL 领域评分较低的最强预测因素。此外，抑郁症状的严重程度与许多 QOL 领域的评分显著相关。
我们的研究结果表明，QOLIE 评分可能受到焦虑症状的存在和严重程度的显著影响，而抑郁症状和病程的严重程度则影响较小。相比之下，临床发作变量与 QOL 的相关性较弱。医疗保健专业人员应该意识到患者情绪状态的重要性及其对 QOL 的作用。
