Zhu Xue-Rui, Zhao Ting, Gu Hao, Gao Ya-Juan, Wang Na, Zhao Pan, Chen Ya-Nan, Han Xiong, He Gui-Nv, Li Ming-Min, Ma Bing-Qian, Yang Shi-Jun
Department of Neurology, Zhengzhou University People's Hospital, Henan Province, Zhengzhou 450003, China.
Department of Neurology, Henan Provincial People's Hospital, Zhengzhou 450003, China.
Epilepsy Behav. 2019 Jan;90:132-136. doi: 10.1016/j.yebeh.2018.11.015. Epub 2018 Dec 7.
The objective of this study was to assess the anxiety and depression of caregivers of adult patients with epilepsy (PWE) and evaluate its effect on patient quality of life (QOL).
One hundred sixty pairs of adult PWE and their caregivers were enrolled in our study. Quality of life in adult PWE was evaluated with the Quality of Life in Epilepsy Inventory-31 scale (QOLIE-31). Symptoms of anxiety and depression in caregivers were assessed with the Hamilton Anxiety Rating Scale (HAM-A) and the Hamilton Depression Rating Scale (HAM-D) respectively. Correlation and stepwise multiple liner regression analyses were used as statistical analysis.
Of the caregivers, 41 (31.30%) had anxiety symptoms (HAM-A scores > 6) and 44 (33.59%) had depression symptoms (HAM-D scores > 6). Caregiver anxiety was significantly associated with poorer adult PWE QOL scores in four of the seven subscales and the QOLIE-31 total score. Caregiver depression was significantly associated with poorer adult PWE QOL in all seven subscales as well as the QOLIE-31 total score. Caregiver depression was an independent predictor of the QOLIE-31 total score and five subscales: seizure worry, emotional wellbeing, energy/fatigue, cognitive, and medication effects.
Caregivers of adult PWE are at high risk of experiencing anxiety and depression. Caregiver psychological status, especially depression, was an independent predictor of poorer QOL for adult PWE.
本研究的目的是评估成年癫痫患者（PWE）照料者的焦虑和抑郁情况，并评估其对患者生活质量（QOL）的影响。
160对成年PWE及其照料者纳入本研究。采用癫痫生活质量量表-31（QOLIE-31）评估成年PWE的生活质量。分别采用汉密尔顿焦虑评定量表（HAM-A）和汉密尔顿抑郁评定量表（HAM-D）评估照料者的焦虑和抑郁症状。采用相关性分析和逐步多元线性回归分析进行统计分析。
在照料者中，41名（31.30%）有焦虑症状（HAM-A评分>6），44名（33.59%）有抑郁症状（HAM-D评分>6）。照料者焦虑与成年PWE七个子量表中的四个以及QOLIE-31总分较低显著相关。照料者抑郁与成年PWE所有七个子量表以及QOLIE-31总分较低显著相关。照料者抑郁是QOLIE-31总分和五个子量表的独立预测因素：癫痫担忧、情绪健康、能量/疲劳、认知和药物影响。
成年PWE的照料者有较高的焦虑和抑郁风险。照料者的心理状态，尤其是抑郁，是成年PWE生活质量较差的独立预测因素。
