Department of Geriatrics, INSERM U558, Toulouse University Hospital Center, Toulouse, France.
Alzheimers Dement. 2011 Jul;7(4):e109-17. doi: 10.1016/j.jalz.2010.05.2020.
The recruitment and retention of patients are among the greatest challenges currently being faced by researchers who conduct Alzheimer's disease (AD) clinical trials. To discuss these challenges and other major issues associated with clinical research in AD, an international workshop was organized by the Association Monégasque pour la recherche sur la Maladie d'Alzheimer at Monte Carlo, Monaco, in February 2010, with the participation of leading research experts in the field of Alzheimer's. Key topics discussed were as follows: (1) the selection, recruitment, and retention of clinical trial subjects; (2) international co-operation among researchers; and (3) patient rights and informed consent for participants in clinical trials. This article highlights some of the challenges faced by investigators when conducting clinical trials in AD, and it also offers some recommendations aimed at overcoming these challenges.
招募和留住患者是目前进行阿尔茨海默病（AD）临床试验的研究人员面临的最大挑战之一。为了讨论这些挑战以及与 AD 临床研究相关的其他主要问题，2010 年 2 月，摩纳哥阿尔茨海默病研究协会在摩纳哥蒙特卡洛组织了一次国际研讨会，邀请了该领域的领先研究专家参加。讨论的主要议题如下：（1）临床试验对象的选择、招募和保留；（2）研究人员之间的国际合作；（3）临床试验参与者的患者权利和知情同意。本文重点介绍了研究人员在进行 AD 临床试验时面临的一些挑战，并提出了一些旨在克服这些挑战的建议。
