Division of Neonatology, Department of Pediatrics, Leiden University Medical Centre, PO Box 9600, 2300 RC, Leiden, The Netherlands.
Early Hum Dev. 2011 Sep;87(9):595-9. doi: 10.1016/j.earlhumdev.2011.07.006. Epub 2011 Jul 23.
Twin-twin transfusion syndrome (TTTS) is a severe complication of monochorionic twin pregnancies associated with high perinatal mortality and morbidity rates. Management in TTTS is a major challenge for obstetricians and neonatologists. Twins which are often born prematurely and may suffer from typical conditions associated with prematurity. In addition, surviving twins with TTTS are at increased risk for other complications including neurological, cardiovascular, renal and hematologic morbidity. Rare complications such as hypoxic-ischemic lesions to limbs or intestines and amniotic band syndrome have also been reported in TTTS survivors. This review focuses on the neonatal and pediatric mortality and morbidity in TTTS survivors, with special emphasis on the long-term neurodevelopmental outcome.
双胎输血综合征（TTTS）是一种严重的单绒毛膜双胞胎妊娠并发症，与围产期高死亡率和高发病率相关。TTTS 的管理对产科医生和新生儿科医生来说是一个重大挑战。双胞胎通常早产，并可能患有与早产相关的典型病症。此外，患有 TTTS 的存活双胞胎还面临其他并发症的风险增加，包括神经、心血管、肾脏和血液学疾病。在 TTTS 幸存者中也有报道罕见并发症，如四肢或肠道缺氧缺血性病变和羊膜带综合征。这篇综述重点关注 TTTS 幸存者的新生儿和儿科死亡率和发病率，特别强调长期神经发育结局。
