Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
Bioorg Med Chem Lett. 2011 Sep 15;21(18):5630-2. doi: 10.1016/j.bmcl.2011.06.036. Epub 2011 Jun 29.
One new phenanthrenedione, pterolinus K (1), and one new chalcone, pterolinus L (2) were isolated from the heartwood extract of Pterocarpus santalinus. The structures were elucidated by spectroscopic methods. Both 1 and 2 showed inhibitory effect on elastase release by human neutrophils in response to fMLP with an IC(50) value of 4.24 and 0.95 μM, and compound 1 also inhibited superoxide anion generation with IC(50) value of 0.99 μM. In addition, compound 1 showed selective cytotoxicity against HepG2 with IC(50) value of 10.86 μM, while compound 2 showed a moderate cytotoxicity against KB with IC(50) values of 17.18 μM.
从紫檀心材提取物中分离得到一个新的菲并二酮类化合物 pterolinus K（1）和一个新的查尔酮类化合物 pterolinus L（2）。通过光谱方法阐明了它们的结构。化合物 1 和 2 均对 fMLP 诱导的人中性粒细胞弹性蛋白酶释放具有抑制作用，IC50 值分别为 4.24 和 0.95 μM，化合物 1 还对超氧阴离子生成具有抑制作用，IC50 值为 0.99 μM。此外，化合物 1 对 HepG2 具有选择性细胞毒性，IC50 值为 10.86 μM，而化合物 2 对 KB 具有中等细胞毒性，IC50 值为 17.18 μM。
