紫檀心材中的生物活性成分。
Bioactive components from the heartwood of Pterocarpus santalinus.
机构信息
Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
出版信息
Bioorg Med Chem Lett. 2011 Sep 15;21(18):5630-2. doi: 10.1016/j.bmcl.2011.06.036. Epub 2011 Jun 29.
One new phenanthrenedione, pterolinus K (1), and one new chalcone, pterolinus L (2) were isolated from the heartwood extract of Pterocarpus santalinus. The structures were elucidated by spectroscopic methods. Both 1 and 2 showed inhibitory effect on elastase release by human neutrophils in response to fMLP with an IC(50) value of 4.24 and 0.95 μM, and compound 1 also inhibited superoxide anion generation with IC(50) value of 0.99 μM. In addition, compound 1 showed selective cytotoxicity against HepG2 with IC(50) value of 10.86 μM, while compound 2 showed a moderate cytotoxicity against KB with IC(50) values of 17.18 μM.
从紫檀心材提取物中分离得到一个新的菲并二酮类化合物 pterolinus K（1）和一个新的查尔酮类化合物 pterolinus L（2）。通过光谱方法阐明了它们的结构。化合物 1 和 2 均对 fMLP 诱导的人中性粒细胞弹性蛋白酶释放具有抑制作用，IC50 值分别为 4.24 和 0.95 μM，化合物 1 还对超氧阴离子生成具有抑制作用，IC50 值为 0.99 μM。此外，化合物 1 对 HepG2 具有选择性细胞毒性，IC50 值为 10.86 μM，而化合物 2 对 KB 具有中等细胞毒性，IC50 值为 17.18 μM。
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