Smonig H, Glaser K H, Höfler H
Institut für Anästhesiologie des LKH Graz.
Anasth Intensivther Notfallmed. 1990 Jan;25 Suppl 1:25-30.
The suitability of triazolam for oral premedication was evaluated in comparison to flunitrazepam. 65 consenting female patients scheduled for gynaecological surgery took part in the trial, were randomly allocated in two groups and were given 0.5 mg triazolam or 2 mg of flunitrazepam as oral premedication 90 min preoperatively. No difference was found in the anxiolytic potency (possible difference d = 0.65 standard deviation, less than 3 points on the anxiety score). Both drugs significantly reduced anxiety (alpha less than 0.01). Anxiolysis depended on the initial anxiety; the higher the initial anxiety score, the better the anxiolytic effect. Triazolam was found to have an antidepressant effect (alpha less than 0.05) and asthenic affects decreased (n.s.). Flunitrazepam had a tendency to increase depression (n.s.) and asthenic effects increased (alpha less than 0.05). No differences were found in the degree of sedation and in the amnestic effect. Systolic pressure remained unchanged in both groups, whereas values of diastolic pressure increased to the same extent in both groups. While heart rate increased after triazolam, it decreased after flunitrazepam. Both groups had comparable initial heart rates. Possible mechanisms to explain this discordance of heart rate-changes are discussed. Triazolam is comparable to flunitrazepam as an oral premedicant and is a suitable drug for short surgical procedures if rapid postoperative recovery is required.
将三唑仑与氟硝西泮进行比较，评估了三唑仑用于口服术前用药的适用性。65名同意参与试验的计划接受妇科手术的女性患者参与了该试验，她们被随机分为两组，并在术前90分钟分别给予0.5毫克三唑仑或2毫克氟硝西泮作为口服术前用药。在抗焦虑效力方面未发现差异（可能差异d = 0.65标准差，焦虑评分低于3分）。两种药物均显著降低了焦虑（α < 0.01）。抗焦虑作用取决于初始焦虑程度；初始焦虑评分越高，抗焦虑效果越好。发现三唑仑具有抗抑郁作用（α < 0.05），且无力感减轻（无统计学意义）。氟硝西泮有增加抑郁的趋势（无统计学意义），且无力感增加（α < 0.05）。在镇静程度和遗忘效果方面未发现差异。两组收缩压均保持不变，而两组舒张压升高幅度相同。三唑仑给药后心率增加，而氟硝西泮给药后心率降低。两组初始心率相当。讨论了解释心率变化这种不一致的可能机制。作为口服术前用药，三唑仑与氟硝西泮相当，对于需要术后快速恢复的短手术操作而言，它是一种合适的药物。
