Department of Experimental Psychology and Physiology of Behaviour, Institute of Neurosciences, Centre for Biomedical Research (CIBM), University of Granada, Campus Cartuja, 18071 Granada, Spain.
Learn Mem. 2011 Jul 22;18(8):529-33. doi: 10.1101/lm.2253311. Print 2011 Aug.
We have investigated the effect of protein kinase Mzeta (PKMζ) inhibition in the basolateral amygdala (BLA) upon the retention of a nonspatial learned active avoidance response and conditioned taste-aversion (CTA) acquisition in rats. ZIP (10 nmol/μL) injected into the BLA 24 h after training impaired retention of a learned avoidance-jumping response assessed 7 d later when compared with control groups injected with scrambled-ZIP. Nevertheless, a retraining session applied 24 h later indicated no differences between the groups. Additionally, a similar ZIP injection into the BLA during the conditioned stimulus-unconditioned stimulus (CS-US) interval attenuated CTA acquisition. These findings support the BLA PKMζ role in various forms of memory.
我们研究了在大鼠中，抑制蛋白激酶 Mzeta（PKMζ）在外侧杏仁核（BLA）中的作用对非空间性习得性回避反应的保留和条件性味觉厌恶（CTA）获得的影响。与注射 scrambled-ZIP 的对照组相比，在训练后 24 小时将 ZIP（10 nmol/μL）注射到 BLA 中会损害 7 天后对习得性回避跳跃反应的保留。然而，24 小时后进行的重新训练表明，两组之间没有差异。此外，在条件刺激-非条件刺激（CS-US）期间将类似的 ZIP 注射到 BLA 中会削弱 CTA 的获得。这些发现支持了 BLA PKMζ 在各种形式的记忆中的作用。
