Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Cancer Epidemiol Biomarkers Prev. 2011 Sep;20(9):1892-901. doi: 10.1158/1055-9965.EPI-11-0399. Epub 2011 Jul 22.
Adipocytokines, adipocyte-secreted hormones, play a critical role in breast cancer development. The expression of visfatin, a newly discovered adipocytokine, in breast cancer tissues was determined and correlated with patient clinicopathologic variables.
Visfatin expression in breast cancer tissues was analyzed by immunohistochemistry. Visfatin expression was correlated with clinicopathologic variables as well as recurrence rates, using the χ(2) test. The prognostic value of visfatin for disease-free and overall survival was evaluated by Kaplan-Meier estimates, and the significance of differences between curves was evaluated by the log-rank test.
High visfatin expression in breast cancer tissues was significantly correlated with tumor size, estrogen receptor (ER) negativity, and progesterone receptor (PR) negativity. Hormone therapy, but not radiotherapy or chemotherapy, decreased the recurrence rate in patients with high visfatin expression. Whereas high visfatin expression alone was associated with poor disease-free and overall survival, worse disease-free and overall survival was observed when high visfatin expression was combined with ER- and PR-negative status. Cox regression analysis also revealed that visfatin is an independent predictor of disease-free and overall survival.
High visfatin expression in breast cancer tissue is associated with more malignant cancer behavior as well as poor patient survival.
Visfatin is an independent prognosis predictor for breast cancer.
脂肪细胞因子是脂肪细胞分泌的激素，在乳腺癌的发生发展中起着关键作用。本研究通过免疫组化的方法检测了一种新发现的脂肪细胞因子内脂素在乳腺癌组织中的表达情况，并分析了它与患者临床病理参数的关系。
应用免疫组化方法检测乳腺癌组织中内脂素的表达情况，采用卡方检验分析内脂素的表达与临床病理参数及复发率的关系。Kaplan-Meier 法进行生存分析，log-rank 检验比较组间差异。
乳腺癌组织中内脂素的高表达与肿瘤大小、雌激素受体（ER）阴性和孕激素受体（PR）阴性相关。激素治疗而非放疗或化疗能降低内脂素高表达患者的复发率。尽管内脂素高表达本身与无病生存率和总生存率降低有关，但当内脂素高表达与 ER 和 PR 阴性状态相结合时，无病生存率和总生存率更差。Cox 回归分析也显示内脂素是无病生存率和总生存率的独立预测因子。
乳腺癌组织中内脂素的高表达与更具侵袭性的肿瘤行为及较差的患者生存率相关。
内脂素是乳腺癌的独立预后预测因子。
