Kakkat Sooraj, Suman Prabhat, Turbat-Herrera Elba A, Singh Seema, Chakroborty Debanjan, Sarkar Chandrani
Department of Pathology, University of South Alabama, Mobile, AL, United States.
Cancer Biology Program, Mitchell Cancer Institute, University of South Alabama, Mobile, AL, United States.
Front Cell Dev Biol. 2024 Jul 8;12:1408844. doi: 10.3389/fcell.2024.1408844. eCollection 2024.
Obesity is a multifaceted metabolic disorder characterized by excessive accumulation of adipose tissue. It is a well-established risk factor for the development and progression of breast cancer. Adipose tissue, which was once regarded solely as a passive energy storage depot, is now acknowledged as an active endocrine organ producing a plethora of bioactive molecules known as adipokines that contribute to the elevation of proinflammatory cytokines and estrogen production due to enhanced aromatase activity. In the context of breast cancer, the crosstalk between adipocytes and cancer cells within the adipose microenvironment exerts profound effects on tumor initiation, progression, and therapeutic resistance. Moreover, adipocytes can engage in direct interactions with breast cancer cells through physical contact and paracrine signaling, thereby facilitating cancer cell survival and invasion. This review endeavors to summarize the current understanding of the intricate interplay between adipocyte-associated factors and breast cancer progression. Furthermore, by discussing the different aspects of breast cancer that can be adversely affected by obesity, this review aims to shed light on potential avenues for new and novel therapeutic interventions.
肥胖是一种多方面的代谢紊乱，其特征是脂肪组织过度积累。它是乳腺癌发生和发展的一个公认的危险因素。脂肪组织曾一度仅被视为一个被动的能量储存库，现在被认为是一个活跃的内分泌器官，能产生大量被称为脂肪因子的生物活性分子，由于芳香化酶活性增强，这些分子会导致促炎细胞因子水平升高和雌激素生成增加。在乳腺癌的背景下，脂肪微环境中脂肪细胞与癌细胞之间的相互作用对肿瘤的起始、进展和治疗耐药性产生深远影响。此外，脂肪细胞可通过物理接触和旁分泌信号与乳腺癌细胞进行直接相互作用，从而促进癌细胞的存活和侵袭。本综述旨在总结目前对脂肪细胞相关因子与乳腺癌进展之间复杂相互作用的理解。此外，通过讨论肥胖可能对乳腺癌产生不利影响的不同方面，本综述旨在阐明新的和新颖的治疗干预的潜在途径。
