Kamoshima Yuuta, Sawamura Yutaka, Sugiyama Taku, Yamaguchi Shigeru, Houkin Kiyohiro, Kubota Kanako
Department of Neurosurgery, Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan.
Neurol Med Chir (Tokyo). 2011;51(7):527-30. doi: 10.2176/nmc.51.527.
A 55-year-old woman presented with an extremely rare primary central nervous system mucosa-associated lymphoid tissue (MALT) lymphoma manifesting as seizure and was subsequently diagnosed with dural MALT lymphoma in the cranium. Magnetic resonance imaging revealed a left frontal dural mass with peritumoral edema. Histological examination of the dural mass confirmed MALT lymphoma and revealed infiltration of small cells with irregular nuclear borders and expression of a B cell marker (CD20) but absence of CD5, CD10, CD23, and cyclinD1. Reactive T-cell infiltration was also seen. Subsequently, local irradiation (40 Gy/20 fractions) was performed. Magnetic resonance imaging showed complete remission just after irradiation was completed. There was no evidence of systemic MALT lymphoma. There has been no recurrence for 3 years without additional therapy.
一名55岁女性因癫痫发作就诊，被诊断为极为罕见的原发性中枢神经系统黏膜相关淋巴组织（MALT）淋巴瘤，随后确诊为颅骨硬脑膜MALT淋巴瘤。磁共振成像显示左侧额叶硬脑膜肿块伴瘤周水肿。硬脑膜肿块的组织学检查确诊为MALT淋巴瘤，可见核边界不规则的小细胞浸润，B细胞标志物（CD20）表达阳性，但CD5、CD10、CD23和细胞周期蛋白D1阴性。还可见反应性T细胞浸润。随后进行了局部放疗（40 Gy/20次分割）。放疗结束后磁共振成像显示完全缓解。无全身MALT淋巴瘤的证据。未经额外治疗，3年来未复发。
