原发性中枢神经系统黏膜相关淋巴组织淋巴瘤——病例报告

Primary central nervous system mucosa-associated lymphoid tissue lymphoma--case report.

作者信息

Kamoshima Yuuta, Sawamura Yutaka, Sugiyama Taku, Yamaguchi Shigeru, Houkin Kiyohiro, Kubota Kanako

机构信息

Department of Neurosurgery, Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan.

出版信息

Neurol Med Chir (Tokyo). 2011;51(7):527-30. doi: 10.2176/nmc.51.527.

DOI:10.2176/nmc.51.527

PMID:21785250

Abstract

A 55-year-old woman presented with an extremely rare primary central nervous system mucosa-associated lymphoid tissue (MALT) lymphoma manifesting as seizure and was subsequently diagnosed with dural MALT lymphoma in the cranium. Magnetic resonance imaging revealed a left frontal dural mass with peritumoral edema. Histological examination of the dural mass confirmed MALT lymphoma and revealed infiltration of small cells with irregular nuclear borders and expression of a B cell marker (CD20) but absence of CD5, CD10, CD23, and cyclinD1. Reactive T-cell infiltration was also seen. Subsequently, local irradiation (40 Gy/20 fractions) was performed. Magnetic resonance imaging showed complete remission just after irradiation was completed. There was no evidence of systemic MALT lymphoma. There has been no recurrence for 3 years without additional therapy.

摘要

一名55岁女性因癫痫发作就诊，被诊断为极为罕见的原发性中枢神经系统黏膜相关淋巴组织（MALT）淋巴瘤，随后确诊为颅骨硬脑膜MALT淋巴瘤。磁共振成像显示左侧额叶硬脑膜肿块伴瘤周水肿。硬脑膜肿块的组织学检查确诊为MALT淋巴瘤，可见核边界不规则的小细胞浸润，B细胞标志物（CD20）表达阳性，但CD5、CD10、CD23和细胞周期蛋白D1阴性。还可见反应性T细胞浸润。随后进行了局部放疗（40 Gy/20次分割）。放疗结束后磁共振成像显示完全缓解。无全身MALT淋巴瘤的证据。未经额外治疗，3年来未复发。