Spine Surgery Department, the Third Hospital of Hebei Medical University, Shijiazhuang, China.
Spine (Phila Pa 1976). 2011 Aug 1;36(17):E1166-72. doi: 10.1097/BRS.0b013e3182127f91.
Case study.
To present three complicated cases of giant cell tumor of the spine treated with sodium ibandronate.
Spinal giant cell tumors are a rare clinical entity with a high recurrence rate after operation. Furthermore, complete resection of such lesions remains a challenging surgical problem. Up to this point, no effective adjuvant therapy has been reported for primary or recurrent spinal giant cell tumors.
One patient with a recurrent giant cell tumor of the seventh thoracic vertebra, one patient with a fifth lumbar vertebral giant cell tumor, and one patient with recurrent giant cell tumor of the sacrum were treated with sodium ibandronate either postoperatively or upon recurrence of the tumor.
The first patient with recurrent thoracic giant cell tumor recovered both clinically and radiologically after treatment with sodium ibandronate without reoperation at 6-years follow-up. The second patient also recovered with no recurrence of the tumor at 4-years follow-up. In the third case, although not fully recovered, the recurrent sacral tumor was under control after treatment with sodium ibandronate at 2-years follow-up.
These case studies demonstrate the potential promise of using sodium ibandronate in the treatment of primary and recurrent giant cell tumors of the spine. Furthermore, clinical evaluation should be performed in future studies.
病例研究。
介绍三例经伊班膦酸钠治疗的脊柱巨细胞瘤复杂病例。
脊柱巨细胞瘤是一种罕见的临床实体，术后复发率高。此外，此类病变的完全切除仍然是一个具有挑战性的手术问题。到目前为止，尚未报道原发性或复发性脊柱巨细胞瘤有有效的辅助治疗方法。
对 1 例复发性第 7 胸椎巨细胞瘤、1 例复发性第 5 腰椎巨细胞瘤和 1 例复发性骶骨巨细胞瘤患者，在术后或肿瘤复发时采用伊班膦酸钠治疗。
第 1 例复发性胸巨细胞瘤患者在接受伊班膦酸钠治疗后，在 6 年的随访中，临床和影像学均恢复，无需再次手术。第 2 例患者在 4 年的随访中也未出现肿瘤复发。第 3 例患者虽然未完全恢复，但在接受伊班膦酸钠治疗后，复发性骶骨肿瘤得到控制，随访 2 年。
这些病例研究表明，伊班膦酸钠在治疗原发性和复发性脊柱巨细胞瘤方面具有潜在的应用前景。此外，未来的研究应进行临床评估。
