Goodman L J, Trenholme G M, Kaplan R L, Segreti J, Hines D, Petrak R, Nelson J A, Mayer K W, Landau W, Parkhurst G W
Department of Medicine, Rush-Presbyterian St Luke's Medical Center, Chicago, IL 60612.
Arch Intern Med. 1990 Mar;150(3):541-6.
From June 1985 to September 1987, 202 adults were enrolled in a randomized, double-blinded study comparing ciprofloxacin (500 mg) with sulfamethoxazole and trimethoprim (160 mg/800 mg) or placebo for adults with acute diarrhea. All patients were treated on the day of presentation and received medication on a twice-daily schedule (every 12 hours) for 5 days. Bacterial isolates from these patients included 35 Campylobacter, 18 Shigella, and 15 Salmonella. Treatment at the time of presentation with ciprofloxacin compared with placebo shortened the duration of diarrhea (2.4 vs 3.4 days), and increased the percentage of patients cured or improved by treatment days 1, 3, 4, and 5. Similar significant differences for sulfamethoxazole and trimethoprim compared with placebo were not seen.
1985年6月至1987年9月，202名成年人参与了一项随机双盲研究，该研究比较了环丙沙星（500毫克）与磺胺甲恶唑和甲氧苄啶（160毫克/800毫克）或安慰剂对患有急性腹泻的成年人的疗效。所有患者在就诊当天接受治疗，并按每日两次（每12小时一次）的给药方案服药5天。这些患者的细菌分离株包括35株弯曲杆菌、18株志贺氏菌和15株沙门氏菌。与安慰剂相比，就诊时使用环丙沙星治疗缩短了腹泻持续时间（2.4天对3.4天），并提高了在治疗第1、3、4和5天时治愈或病情改善的患者百分比。与安慰剂相比，未观察到磺胺甲恶唑和甲氧苄啶有类似的显著差异。
