Department of Radiology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan.
Jpn J Radiol. 2011 Jul;29(6):378-85. doi: 10.1007/s11604-011-0567-9. Epub 2011 Jul 24.
The aim of this study was to determine whether non-contrast-enhanced magnetic resonance imaging (MRI) can detect three levels of renal impairment by evaluating the differences and agreement with (99m)Tc-diethylenetriamine pentaacetic acid (DTPA) renography.
A total of 28 patients with kidney disease were enrolled in the study. MRI findings, including visual corticomedullary differentiation (CMD) on T1- and T2-weighted imaging (T1WI, T2WI), cortical irregularity, the number of renal cysts, and the volume of the kidney, were evaluated for individual kidneys and pairs of kidneys. The differences and agreement between MRI findings and the three levels of renal impairment based on the glomerular filtration rate (GFR) measured using (99m)Tc-DTPA renography were analyzed.
All MRI findings except the number of renal cysts in pairs of kidneys were consistent with the patient's classification. The agreement between the patient's classifications based on GFR and that based on the visual CMD on T1WI and T2WI was almost perfect or substantial in both individual kidneys and pairs of kidneys.
Non-contrast-enhanced MRI was capable of distinguishing three levels of renal function, including serious renal impairment.
本研究旨在通过评估（99m）Tc-二乙三胺五乙酸（DTPA）肾动态显像与非增强磁共振成像（MRI）的差异和一致性，来确定非增强 MRI 是否可以检测到三个级别的肾功能损害。
共纳入 28 例肾脏疾病患者。对 MRI 表现，包括 T1 加权成像（T1WI）和 T2 加权成像（T2WI）的皮质髓质分化（CMD）、皮质不规则、肾囊肿数量以及肾脏体积等，进行个体肾脏和对侧肾脏的评估。分析 MRI 表现与基于（99m）Tc-DTPA 肾动态显像测量的肾小球滤过率（GFR）的三个级别肾功能损害之间的差异和一致性。
除了对侧肾脏的肾囊肿数量外，所有 MRI 表现均与患者的分类一致。在个体肾脏和对侧肾脏中，基于 GFR 的患者分类与基于 T1WI 和 T2WI 的视觉 CMD 的分类之间的一致性近乎完美或高度一致。
非增强 MRI 能够区分包括严重肾功能损害在内的三个级别的肾功能。
