急性注射胰岛素对糖尿病大鼠胆汁脂质分泌的影响。
Effect of acute insulin administration on biliary lipid secretion by the diabetic rat.
作者信息
Villanueva G R, Herreros M, Perez-Barriocanal F, Fernandez E, Marin J J
机构信息
Department of Physiology and Pharmacology, University of Salamanca, Spain.
出版信息
J Exp Pathol (Oxford). 1990 Feb;71(1):89-94.
The insulin-deficient state induces profound changes in bile formation. The present work was to test the effect of acute insulin administration on lipid secretion into bile in diabetic rats. Diabetes was induced by streptozotocin injection (6 mg/100 g body-weight, i.p., 6 days before the experiments). Bile formation was stimulated by taurocholate infusion (0.5 mumol/min/100 g body-weight). Intravenous administration of insulin (bolus: 100 mU/100 g body-weight, plus infusion: 5 mU/min/100 g body-weight) induced choleresis accompanied by a slight and transient enhancement in bile acid output which was similar to that found in lecithin and cholesterol output in the control group. However, insulin induced a rapid and significant (P less than 0.05) reduction in biliary lipid output in the diabetic rats. These results suggest that insulin may play an important role in mechanisms other than synthesis involved in the supply of biliary lipids towards the canaliculi.
胰岛素缺乏状态会引起胆汁形成的深刻变化。本研究旨在测试急性给予胰岛素对糖尿病大鼠胆汁脂质分泌的影响。通过注射链脲佐菌素（6毫克/100克体重，腹腔注射，在实验前6天）诱导糖尿病。通过输注牛磺胆酸盐（0.5微摩尔/分钟/100克体重）刺激胆汁形成。静脉注射胰岛素（推注：100毫单位/100克体重，加输注：5毫单位/分钟/100克体重）诱导胆汁分泌增加，同时胆汁酸输出有轻微且短暂的增加，这与对照组卵磷脂和胆固醇输出的情况相似。然而，胰岛素使糖尿病大鼠的胆汁脂质输出迅速且显著降低（P<0.05）。这些结果表明，胰岛素可能在除合成之外的机制中发挥重要作用，这些机制涉及向胆小管供应胆汁脂质。
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