铜催化的芳基碘化物、溴化物和氯化物的羟化反应高效合成酚类。
Highly efficient synthesis of phenols by copper-catalyzed hydroxylation of aryl iodides, bromides, and chlorides.
机构信息
Laboratory of Regenerative Biology, Guangzhou Institute of Biomedicine and Health, CAS, Guangzhou, 510530, PR China.
出版信息
Org Lett. 2011 Aug 19;13(16):4340-3. doi: 10.1021/ol2016737. Epub 2011 Jul 25.
PMID:21786767
Abstract
8-Hydroxyquinolin-N-oxide was found to be a very efficient ligand for the copper-catalyzed hydroxylation of aryl iodides, aryl bromides, or aryl chlorides under mild reaction conditions. This methodology provides a direct transformation of aryl halides to phenols and to alkyl aryl ethers. The inexpensive catalytic system showed great functional group tolerance and excellent selectivity.
摘要
8-羟基喹啉-N-氧化物被发现是一种非常有效的配体，可在温和的反应条件下催化铜催化的芳基碘化物、芳基溴化物或芳基氯化物的羟基化反应。该方法为芳基卤化物直接转化为酚和芳基烷基醚提供了一种途径。该廉价的催化体系具有很好的官能团耐受性和优异的选择性。
Zotero 插件