Liu Yajun, Liu Shasha, Xiao Yan
College of Life Science and Medicine, Dalian University of Technology, Panjin 124221, China.
Department of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China.
Beilstein J Org Chem. 2017 Mar 23;13:589-611. doi: 10.3762/bjoc.13.58. eCollection 2017.
Phenols and aryl thiols are fundamental building blocks in organic synthesis and final products with interesting biological activities. Over the past decades, substantial progress has been made in transition-metal-catalyzed coupling reactions, which resulted in the emergence of new methods for the synthesis of phenols and aryl thiols. Aryl halides have been extensively studied as substrates for the synthesis of phenols and aryl thiols. In very recent years, C-H activation represents a powerful strategy for the construction of functionalized phenols directly from various arenes. However, the synthesis of aryl thiols through C-H activation has not been reported. In this review, a brief overview is given of the recent advances in synthetic strategies for both phenols and aryl thiols.
酚类和芳基硫醇是有机合成中的基本结构单元，也是具有有趣生物活性的最终产物。在过去几十年中，过渡金属催化的偶联反应取得了重大进展，这导致了合成酚类和芳基硫醇的新方法的出现。芳基卤化物作为合成酚类和芳基硫醇的底物已得到广泛研究。近年来，C-H活化是一种直接从各种芳烃构建官能化酚类的强大策略。然而，尚未有通过C-H活化合成芳基硫醇的报道。在本综述中，简要概述了酚类和芳基硫醇合成策略的最新进展。
