Clinical Neurosciences Division, Moorgreen Hospital, University of Southampton, Botley Road, Southampton SO30 3JB, UK.
Biochem Soc Trans. 2011 Aug;39(4):898-901. doi: 10.1042/BST0390898.
A number of studies demonstrate disturbances of the central innate immune system in AD (Alzheimer's disease). In animal and human studies, there is evidence of close communication between systemic and central innate immune systems. Animal models of neurodegeneration show evidence of an exaggerated central innate immune response following systemic inflammation. Clinical studies of AD show evidence of increased cognitive decline and exaggerated sickness behaviour in response to systemic inflammation. Recognition of this communication pathway offers alternative explanations for a number of recognized risk factors in the development and progression of AD and highlights the potential of the manipulation of systemic innate immunity as a novel therapeutic approach.
多项研究表明，阿尔茨海默病（AD）患者的中枢固有免疫系统存在紊乱。在动物和人体研究中，有证据表明全身和中枢固有免疫系统之间存在密切的通讯。神经退行性变动物模型显示，全身炎症后中枢固有免疫反应增强。AD 的临床研究表明，全身炎症反应会导致认知能力下降加剧和病态行为加重。认识到这种通讯途径为 AD 发生和进展过程中的许多公认的风险因素提供了另一种解释，并强调了操纵全身固有免疫的潜力，这可能成为一种新的治疗方法。
