Gupta A, Pansari K
University Department of Geriatric Medicine, Llandough Hospital, Penarth, Glamorgan, UK.
Int J Clin Pract. 2003 Jan-Feb;57(1):36-9.
Alzheimer's disease (AD) is classified mainly as a neurodegenerative disease. Recent research, however, has shown that inflammatory mechanisms are also associated with AD and that they could have a role in contributing to the pathogenesis of this disease. The evidence is based on histopathological brain studies, laboratory studies of peripheral inflammation and the fact that certain anti-inflammatory drugs could modify the course of AD. There is wide scope for further research using anti-inflammatory therapies in the prevention/treatment of AD, thereby reducing the burden of this widely prevalent condition in the community.
阿尔茨海默病（AD）主要被归类为一种神经退行性疾病。然而，最近的研究表明，炎症机制也与AD有关，并且它们可能在促成这种疾病的发病机制中发挥作用。证据基于脑的组织病理学研究、外周炎症的实验室研究以及某些抗炎药物可以改变AD病程这一事实。在AD的预防/治疗中使用抗炎疗法进行进一步研究有广阔的空间，从而减轻社区中这种广泛流行疾病的负担。
