神经退行性变能否与慢性特发性人类神经退行性疾病的神经病理学特征分离？建模视角！

Can neurodegeneration be separated from neuropathological hallmarks of chronic idiopathic human neurodegenerative disease? A perspective from modelling!

机构信息

School of Biomedical Sciences, University of Nottingham Medical School, Queen's Medical Centre, Nottingham NG7 2UH, UK.

出版信息

Biochem Soc Trans. 2011 Aug;39(4):917-9. doi: 10.1042/BST0390917.

Abstract

Chronic neurodegenerative disease is characterized by extensive regional loss of neurons in the brain and neuropathological hallmarks in surviving neurones. Genetic modelling by overexpression of hallmark proteins does not produce extensive neurodegeneration, whereas genetic deletion of neuronal 26S proteasomes does, as well as some hallmarks of human disease.

摘要

慢性神经退行性疾病的特征是大脑中广泛的区域神经元丧失和存活神经元中的神经病理学特征。通过过度表达标志性蛋白进行遗传建模不会导致广泛的神经退行性变，而神经元 26S 蛋白酶体的遗传缺失以及人类疾病的一些特征则会导致这种情况。