Inserm Research Center UMR866-Lipids, Nutrition, Cancer, University of Burgundy-Medical School, 7 boulevard Jeanne d'Arc, BP87900, 21079 Dijon Cedex, France.
Biochem Soc Trans. 2011 Aug;39(4):984-8. doi: 10.1042/BST0390984.
Plasma PLTP (phospholipid-transfer protein) is a member of the lipid transfer/LBP [LPS (lipopolysaccharide)-binding protein] family, which constitutes a superfamily of genes together with the short and long PLUNC (palate, lung and nasal epithelium clone) proteins. Although PLTP was studied initially for its involvement in the metabolism of HDL (high-density lipoproteins) and reverse cholesterol transport (i.e. the metabolic pathway through which cholesterol excess can be transported from peripheral tissues back to the liver for excretion in the bile), it displays a number of additional biological properties. In particular, PLTP can modulate the lipoprotein association and metabolism of LPS that are major components of Gram-negative bacteria. The delayed association of LPS with lipoproteins in PLTP-deficient mice results in a prolonged residence time, in a higher toxicity of LPS aggregates and in a significant increase in LPS-induced mortality as compared with wild-type mice. It suggests that PLTP may play a pivotal role in inflammation and innate immunity through its ability to accelerate the 'reverse LPS transport' pathway.
血浆 PLTP（磷脂转运蛋白）是脂质转运/LBP[LPS（脂多糖）结合蛋白]家族的成员，该家族与短和长 PLUNC（腭、肺和鼻上皮克隆）蛋白一起构成了一个基因超家族。虽然最初研究 PLTP 是因为其参与了 HDL（高密度脂蛋白）和胆固醇逆转运（即胆固醇过剩可以从外周组织运输回肝脏以胆汁形式排泄的代谢途径）的代谢，但它显示出许多其他生物学特性。特别是，PLTP 可以调节 LPS（革兰氏阴性菌的主要成分）与脂蛋白的关联和代谢。PLTP 缺乏的小鼠中 LPS 与脂蛋白的关联延迟，导致 LPS 聚集的半衰期延长，毒性更高，LPS 诱导的死亡率显著增加，与野生型小鼠相比。这表明 PLTP 通过加速“反向 LPS 转运”途径，可能在炎症和先天免疫中发挥关键作用。
