Ford Kevin J, Feller Marla B
Department of Molecular and Cellular Biology, University of California, Berkeley, CA 94720-3200, USA.
Vis Neurosci. 2012 Jan;29(1):61-71. doi: 10.1017/S0952523811000216. Epub 2011 Jul 26.
In the few weeks prior to the onset of vision, the retina undergoes a dramatic transformation. Neurons migrate into position and target appropriate synaptic partners to assemble the circuits that mediate vision. During this period of development, the retina is not silent but rather assembles and disassembles a series of transient circuits that use distinct mechanisms to generate spontaneous correlated activity called retinal waves. During the first postnatal week, this transient circuit is comprised of reciprocal cholinergic connections between starburst amacrine cells. A few days before the eyes open, these cholinergic connections are eliminated as the glutamatergic circuits involved in processing visual information are formed. Here, we discuss the assembly and disassembly of this transient cholinergic network and the role it plays in various aspects of retinal development.
在视觉开始形成的前几周，视网膜经历了巨大的转变。神经元迁移到合适的位置，并与适当的突触伙伴建立联系，以组装介导视觉的神经回路。在这个发育阶段，视网膜并非处于静止状态，而是组装并拆解了一系列短暂的神经回路，这些回路利用不同的机制产生称为视网膜波的自发相关活动。在出生后的第一周，这个短暂的神经回路由星爆无长突细胞之间的相互胆碱能连接组成。在眼睛睁开前几天，随着参与处理视觉信息的谷氨酸能神经回路的形成，这些胆碱能连接被消除。在这里，我们讨论这个短暂胆碱能网络的组装和拆解过程，以及它在视网膜发育各个方面所起的作用。
