Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar 608002, Tamilnadu, India.
Environ Toxicol Pharmacol. 2010 Jan;29(1):50-7. doi: 10.1016/j.etap.2009.09.006. Epub 2009 Oct 7.
Morin is a flavonoid present in fruits and Chinese herbs, exhibits various beneficial biological activities. There are numerous evidence suggesting that total dietary fat intake is generally associated with early promotion of colon cancer, the alterations in the lipid profile is important for malignant transformation and tumor development and carbohydrate moieties of glycoproteins reflect the stage of cancer. Aberrant crypt foci (ACF) consisting of morphologically irregular crypts, are thought to be precancerous lesions for colon cancer. Our aim was to study the inhibitory effect morin on aberrant crypt foci and alterations in the levels of lipids, and glycoconjugates in experimental rat colon cancer. Group 1 served as control, groups 2 and 4 received 50mg/kg b.w. morin orally everyday for 30 weeks. Groups 3 and 4 were given subcutaneous injection of 1,2-dimethylhydrazine (DMH) 20mg/kg b.w. for the first 15 weeks. Administration of morin at the dose of 50mg/kg b.w., significantly suppressed the formation of ACF its multiplicity and lowered levels of serum and tissue lipids, cholesterol-phospholipid ratio, glycoconjugate and also increased the activity of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG CoA reductase). These results indicate that morin has a protective effect against DMH-induced colon carcinogenesis.
莫林是一种存在于水果和中药中的类黄酮，具有多种有益的生物活性。有大量证据表明，总膳食脂肪摄入量通常与结肠癌的早期促进有关，脂质谱的改变对恶性转化和肿瘤发展很重要，糖蛋白的碳水化合物部分反映了癌症的阶段。形态不规则的隐窝组成的异常隐窝（ACF）被认为是结肠癌的癌前病变。我们的目的是研究莫林对实验性大鼠结肠癌中异常隐窝和脂质及糖缀合物水平变化的抑制作用。第 1 组作为对照，第 2 组和第 4 组每天口服 50mg/kg b.w.莫林 30 周。第 3 组和第 4 组在前 15 周内皮下注射 1,2-二甲基肼（DMH）20mg/kg b.w.。莫林的剂量为 50mg/kg b.w.时，能显著抑制 ACF 的形成及其多发性，并降低血清和组织脂质、胆固醇-磷脂比、糖缀合物的水平，同时增加 3-羟-3-甲基戊二酰辅酶 A 还原酶（HMG CoA 还原酶）的活性。这些结果表明，莫林对 DMH 诱导的结肠癌发生具有保护作用。
