Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar, Tamil Nadu, India.
Redox Rep. 2012;17(4):167-75. doi: 10.1179/1351000212Y.0000000015. Epub 2012 Jul 9.
This study was undertaken to investigate the antihypertensive and antihyperlipedimic potential of morin against deoxycorticosterone acetate (DOCA)-salt hypertensive rats.
Hypertension was induced in uninephrectomized rats (UNX) by weekly twice subcutaneous injection of DOCA (25 mg/kg) and 1% NaCl in the drinking water for six consecutive weeks. Morin (50 mg/kg) was administered to DOCA-salt rats orally using an intragastric tube daily for a period of 6 weeks.
The DOCA-salt hypertensive rats showed significant elevation in mean arterial pressure (MAP), heart rate (HR) and reduction in body weight. A significant increase in the concentrations of plasma and tissue (liver, kidney, heart, and aorta) lipids such as total cholesterol, triglycerides, free fatty acids, phospholipids, plasma low-density and very low-density lipoproteins cholesterol, and a decrease in the concentration of high-density lipoprotein cholesterol were noticed in DOCA-salt hypertensive rats. Also, the levels of urinary protein and the activity of 3-hydroxy 3-methylglutaryl coenzyme A reductase in the plasma and tissues were increased, and lecithin cholesterol acyl transferase activity in the plasma was decreased in DOCA-salt rats. Morin supplementation (50 mg/kg) throughout the experimental period restored all the above parameters significantly.
Morin has a potential role in attenuating severe hypertension and hyperlipedimia.
本研究旨在探讨桑色素对去氧皮质酮醋酸盐（DOCA）-盐高血压大鼠的降压和抗高脂血症作用。
通过每周两次向单侧肾切除大鼠（UNX）皮下注射 DOCA（25mg/kg）和饮用水中的 1%NaCl，连续 6 周诱导高血压。Morin（50mg/kg）通过胃管每日口服给予 DOCA-盐大鼠，持续 6 周。
DOCA-盐高血压大鼠的平均动脉压（MAP）、心率（HR）显著升高，体重减轻。血浆和组织（肝、肾、心和主动脉）脂质浓度如总胆固醇、甘油三酯、游离脂肪酸、磷脂、血浆低密度和极低密度脂蛋白胆固醇显著升高，高密度脂蛋白胆固醇浓度降低。此外，DOCA-盐高血压大鼠的血浆和组织中尿蛋白水平和 3-羟基-3-甲基戊二酰辅酶 A 还原酶活性升高，血浆中卵磷脂胆固醇酰基转移酶活性降低。Morin 补充（50mg/kg）在整个实验期间显著恢复了所有上述参数。
Morin 具有减轻严重高血压和高脂血症的潜力。
