Department of Public Health, University of Szeged Faculty of Medicine, H-6720 Szeged, Dóm tér 10, Hungary.
Environ Toxicol Pharmacol. 2010 Sep;30(2):121-6. doi: 10.1016/j.etap.2010.04.006. Epub 2010 May 26.
Airborne manganese represents a major risk of nervous system damage first of all in industrial settings. The resulting effects may depend on the dose and physicochemical form of Mn. To compare the effect of soluble and nanoparticulate Mn, adult male rats received daily instillation of MnCl(2) solution or MnO(2) nanoparticle suspension (dose: 2.53mg Mn per rat) into the nasal cavity for 3 and 6 weeks. At the end of treatment, spontaneous open field motility was tested, electrophysiological recording was done in anesthesia, and brain tissue Mn level was determined. Metal level increase in the rats' brain, body weight gain reduction, and decrease of open field motility was significant in the MnCl(2), but not nano-Mn, treated rats. Most evoked cortical activity parameters were significantly altered in both groups, but spontaneous cortical activity spectrum only in the rats receiving MnCl(2). There was fair correlation between brain Mn levels and certain neuro-functional parameters, underlining the causal relationship. Electrophysiological tests might be more sensitive to the effects of Mn than general toxicological or neurobehavioral tests.
空气中的锰首先对工业环境中的神经系统造成严重损害。其产生的影响可能取决于锰的剂量和物理化学形态。为了比较可溶性锰和纳米锰的作用，成年雄性大鼠每天通过鼻腔滴注 MnCl2 溶液或 MnO2 纳米颗粒悬浮液（剂量：每只大鼠 2.53mg Mn），持续 3 周和 6 周。在治疗结束时，进行自发旷场运动测试，在麻醉状态下进行电生理记录，并测定脑组织中的锰含量。在 MnCl2 处理组，而不是纳米 Mn 处理组，大鼠的脑组织金属含量增加、体重增加减少、旷场运动减少，差异有统计学意义。两组的大多数诱发电皮质活动参数均有显著改变，但只有在接受 MnCl2 处理的大鼠中，自发皮质活动谱发生了改变。脑锰含量与某些神经功能参数之间存在较好的相关性，这强调了两者之间的因果关系。电生理测试可能比一般的毒理学或神经行为学测试更敏感地反映锰的作用。
