铝纳米颗粒暴露在 L1 幼虫中会比在 L4 幼虫或成虫中导致更严重的致死毒性，这是通过增强线虫的应激反应形成和肠道脂褐素积累实现的。
Aluminum nanoparticle exposure in L1 larvae results in more severe lethality toxicity than in L4 larvae or young adults by strengthening the formation of stress response and intestinal lipofuscin accumulation in nematodes.
机构信息
Key Laboratory of Developmental Genes and Human Disease in Ministry of Education, Institute of Life Sciences, Southeast University, Nanjing 210009, China.
出版信息
Environ Toxicol Pharmacol. 2011 Jan;31(1):179-88. doi: 10.1016/j.etap.2010.10.005. Epub 2010 Oct 23.
Toxicity of Al(2)O(3)-NPs, as compared to that of Al(2)O(3), to L1-larval, L4-larval or young adult nematodes was evaluated. When exposure was performed at L1-larval stage, the significant increases of lethality, stress response, and intestinal lipofuscin autofluorescence were observed in 6.3-203.9 mg/L of Al(2)O(3)-NPs exposed nematodes. In contrast, when exposure was performed at L4-larval or young adult stage, the significant increases of lethality and intestinal lipofuscin autofluorescence were observed in 12.7-203.9 mg/L of Al(2)O(3)-NPs exposed nematodes, and the significant inductions of stress response were detected in 25.5-203.9 mg/L of Al(2)O(3)-NPs exposed nematodes. Moreover, the lethality was significantly correlated with the stress response and the intestinal lipofuscin autofluorescence in Al(2)O(3)-NPs exposed nematodes. These data imply that Al(2)O(3)-NPs exposure in L1 larvae causes more severe lethality toxicity than in L4 larvae or young adults by strengthening the formation of stress response and intestinal lipofuscin accumulation in nematodes.
研究了与氧化铝相比，纳米氧化铝（Al2O3-NPs）对 L1 幼虫、L4 幼虫或幼成体线虫的毒性。当在 L1 幼虫阶段进行暴露时，在 6.3-203.9 mg/L 的 Al2O3-NPs 暴露的线虫中观察到致死率、应激反应和肠道脂褐素自发荧光显著增加。相比之下，当在 L4 幼虫或幼成体阶段进行暴露时，在 12.7-203.9 mg/L 的 Al2O3-NPs 暴露的线虫中观察到致死率和肠道脂褐素自发荧光显著增加，在 25.5-203.9 mg/L 的 Al2O3-NPs 暴露的线虫中观察到应激反应显著诱导。此外，在 Al2O3-NPs 暴露的线虫中，致死率与应激反应和肠道脂褐素自发荧光显著相关。这些数据表明，在 L1 幼虫中暴露 Al2O3-NPs 比在 L4 幼虫或幼成体中更能通过增强线虫应激反应和肠道脂褐素积累来引起更严重的致死毒性。
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