Department of Environmental and Molecular Health Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto 862-0973, Japan.
Environ Toxicol Pharmacol. 2011 May;31(3):496-9. doi: 10.1016/j.etap.2011.03.008. Epub 2011 Mar 15.
The effects of aging and an ovariectomy operation on the brain-disrupting actions caused by prenatal exposure to diethylstilbestrol (DES) were studied in mice. In the young DES-exposed female mice, the level of hippocampal phosphorylated CaM kinase II (pCaMKII) was not changed. However, at 8 months, the level of hippocampal pCaMKII in the DES-exposed female mice significantly increased compared to control. Moreover, the ovariectomy significantly increased the level of pCaMKII in the hippocampus but not the cortex of DES-exposed female mice. These findings suggest that the influence of prenatally-exposed DES on the hippocampal pCaMKII may be affected by the endogenous female sex hormones such as estrogen.
本研究旨在探讨衰老和卵巢切除术对产前暴露于己烯雌酚（DES）引起的大脑损伤的影响。在年轻的 DES 暴露雌性小鼠中，海马磷酸化钙调蛋白激酶 II（pCaMKII）的水平没有改变。然而，在 8 个月时，DES 暴露雌性小鼠的海马 pCaMKII 水平与对照组相比显著增加。此外，卵巢切除术显著增加了 DES 暴露雌性小鼠海马但不皮质的 pCaMKII 水平。这些发现表明，产前暴露于 DES 对海马 pCaMKII 的影响可能受到内源性女性性激素（如雌激素）的影响。
