Steroid binding properties of beef adrenal cortical cytochrome P-450 which catalyzes the conversion of cholesterol into pregnenolone.

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作者信息

Orme-Johnson N R, Light D R, White-Stevens R W, Orme-Johnson W H

出版信息

J Biol Chem. 1979 Mar 25;254(6):2103-11.

PMID:217878

Abstract

摘要

相似文献

Steroid binding properties of beef adrenal cortical cytochrome P-450 which catalyzes the conversion of cholesterol into pregnenolone.

J Biol Chem. 1979 Mar 25;254(6):2103-11.

The role of cytochrome P-450 in the regulation of steroid biosynthesis.细胞色素P-450在甾体生物合成调控中的作用。

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Beef adrenal cortical cytochrome P-450 which catalyzes the conversion of cholesterol to pregnenolone. Oxidation-reduction potentials of the free, steroid-complexed, and adrenodoxin-complexed P-450.

J Biol Chem. 1981 Jan 10;256(1):343-50.

Biosynthesis of pregnenolone from cholesterol by mitochondrial enzymes of bovine adrenal cortex. The question of the participation of the 20(22)-olefins and 20, 22-epoxides of cholesterol.

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Evidence That Compound I Is the Active Species in Both the Hydroxylase and Lyase Steps by Which P450scc Converts Cholesterol to Pregnenolone: EPR/ENDOR/Cryoreduction/Annealing Studies.细胞色素P450胆固醇侧链裂解酶（P450scc）将胆固醇转化为孕烯醇酮的羟化酶和裂解酶步骤中，化合物I均为活性物种的证据：电子顺磁共振/电子核双共振/低温还原/退火研究

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Cholesterol side-chain cleavage, cytochrome P450, and the control of steroidogenesis.胆固醇侧链裂解、细胞色素P450与类固醇生成的调控

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The transfer of cholesterol and hydroxycholesterol derivatives from liposome to soluble cytochrome P-450 scc.胆固醇和羟基胆固醇衍生物从脂质体到可溶性细胞色素P-450 scc的转移。

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The enzyme activity of bovine adrenocortical cytochrome P-450 producing pregnenolone from cholesterol: kinetic and electrophoretic studies on the reactivity of hydroxycholesterol intermediates.

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Side-chain specificities of human and bovine cytochromes P-450scc.人及牛细胞色素P-450scc的侧链特异性

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Cytochrome P-450 of adrenal mitochondria. Steroid binding sites on two distinguishable forms of rat adrenal mitochondrial cytochrome P-450sec.肾上腺线粒体的细胞色素P - 450。大鼠肾上腺线粒体细胞色素P - 450sec两种可区分形式上的类固醇结合位点。

J Biol Chem. 1977 Dec 25;252(24):8788-96.

引用本文的文献

Biochemistry. 2015 Dec 8;54(48):7089-97. doi: 10.1021/acs.biochem.5b00903. Epub 2015 Nov 25.

Compound I is the reactive intermediate in the first monooxygenation step during conversion of cholesterol to pregnenolone by cytochrome P450scc: EPR/ENDOR/cryoreduction/annealing studies.I 型化合物是细胞色素 P450scc 将胆固醇转化为孕烯醇酮过程中第一步单加氧反应的活性中间体：EPR/ENDOR/低温还原/退火研究。

J Am Chem Soc. 2012 Oct 17;134(41):17149-56. doi: 10.1021/ja3067226. Epub 2012 Oct 5.

Features of the retinal environment which affect the activities and product profile of cholesterol-metabolizing cytochromes P450 CYP27A1 and CYP11A1.影响胆固醇代谢细胞色素 P450 CYP27A1 和 CYP11A1 活性和产物特征的视网膜环境特征。

Arch Biochem Biophys. 2012 Feb 15;518(2):119-26. doi: 10.1016/j.abb.2011.12.016. Epub 2011 Dec 29.

Structural basis for three-step sequential catalysis by the cholesterol side chain cleavage enzyme CYP11A1.胆固醇侧链裂解酶 CYP11A1 的三步连续催化的结构基础。

J Biol Chem. 2011 Feb 18;286(7):5607-13. doi: 10.1074/jbc.M110.188433. Epub 2010 Dec 15.

Steroidogenic electron transport in adrenal cortex mitochondria.肾上腺皮质线粒体中的类固醇生成电子传递

Mol Cell Biochem. 1982 May 28;45(1):13-31. doi: 10.1007/BF01283159.

Proximity of the substrate binding site and the heme-iron catalytic site in cytochrome P-450scc.细胞色素P-450侧链裂解酶中底物结合位点与血红素铁催化位点的接近性。

Proc Natl Acad Sci U S A. 1982 Oct;79(19):5773-7. doi: 10.1073/pnas.79.19.5773.

ACTH stimulation on cholesterol side chain cleavage activity of adrenocortical mitochondria. Transfer of the stimulus from plasma membrane to mitochondria.促肾上腺皮质激素对肾上腺皮质线粒体胆固醇侧链裂解活性的刺激作用。刺激从质膜向线粒体的传递。

Mol Cell Biochem. 1981 Apr 27;36(2):105-22. doi: 10.1007/BF02354909.

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